Monday, August 12, 2019
Advanced and Clinical Immunology Essay Example | Topics and Well Written Essays - 1000 words
Advanced and Clinical Immunology - Essay Example Consequently, IgE immunoblotting was mainly required for determination of the foods to evade in trying to help the patient feel better ((Phipatanakul et al, 2004). 4. Th-2 like cells can be identified in the peripheral blood and lesions of atopic-dermatitis patients producing IL-4, 5, 13 and also IL-17 from Th17 cells. Explain the role(s) of these cytokines in allergy (10 Marks). Ã IL-4, 5, 13 are important for allergic responses and elimination of parasites. Th17 cells are the newest members of the Th cell family and produce the IL-17. The Th17 cells are involved in host defense with a role of protection against extracellular bacteria through activity on both the immune and non-immune cells, they have also begun to be associated with the pathophysiology development of allergic diseases such as atopic dermatitis (Cox, et al, 2008). Ã Mast cells PGDs, Basophil histamine and Eosinophil Cationic Protein (ECP) are essential constituents of allergic inflammation. Succeeding fixation of IgE to FceRI receptors on mast cells and basophil histamine is vital to the initiation and proliferation of immediate hypersensitivity reactions. Mast cells, basophils, and the eosinophils are major effector cells in the allergic inflammation (Yazdanbakhsh et al, 2002). Mast cells indirectly contribute to asthmatic reactions. Its presence causes A when the activation by multivalent Ag and the IgE, mast cells produces many inflammatory mediators, which includes histamines, eicosanoids, and proteases with PGD2 in high quantity.